nephroprotective activity of mammea africana stem bark against paracetamol induced kidney injury

background & aim: mammea africana sabine (guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. experimental:  the nephroprotective effect of the extract was evaluated by the determination of some kidney function parameters such as serum urea and creatinine, electrolyes (k+, na+, cl- and hco-3),  antioxidant enzymes (superoxide dismutase (sod), catalase (cat), reduced glutathione (gsh), malondialdehyde (mda) and histopathological study of the liver. results & discussion: the administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. the electrolytes levels were not affected. histology of the kidney sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. the chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective effect of the stembark extract of m. africana recommended applications/industries: the results show that the stembark extract of mammea africana has nephroprotective potential which may be due to its antioxidant effect activity.